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KAP - Ketamine Assisted Psychotherapy

Available January 2027

A neuroscience-informed approach to healing, emotional flexibility, and meaningful change.

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Sometimes, even when we understand our patterns, it can feel difficult to make lasting changes. Ketamine-Assisted Psychotherapy (KAP) combines the therapeutic use of ketamine with intentional psychological support to create opportunities for new perspectives, emotional insight, and deeper therapeutic work.

KAP may help create space to step outside familiar thought patterns, explore emotions differently, and reconnect with parts of yourself that may feel difficult to access.

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What is Ketamine-Assisted Psychotherapy (KAP)?

Ketamine-Assisted Psychotherapy (KAP) is an approach that combines ketamine treatment with psychotherapy and integration. Ketamine is a medication that has been used in medical settings for decades, and research has explored its potential to reduce symptoms of depression and other mental health concerns.

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Unlike traditional talk therapy alone, KAP incorporates the effects of ketamine into a structured therapeutic process. Ketamine can temporarily alter perception, awareness, and the way you experience thoughts and emotions. Some people describe feeling less connected to their usual patterns of thinking, allowing them to explore experiences from a different perspective.

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The goal is not simply to have an experience, but to use that experience as an opportunity for therapeutic growth. With preparation, support, and integration, we can work together to explore what comes up and connect those insights to meaningful changes in your everyday life.

 

KAP is not about losing control or pursuing a psychedelic experience. It is about creating a safe, intentional, and supported space for healing and renewal.

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How does Ketamine-Assisted Psychotherapy work?

There are three important parts of the KAP process. Each plays a role in helping you prepare, engage in the experience, and work toward lasting change.

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1. Preparation and intention setting

We begin by getting to know you, your history, current challenges, and goals for therapy. We will discuss what you hope to explore and establish a foundation of safety, trust, and emotional support. Preparation may include identifying intentions, developing grounding strategies, and discussing what to expect during the experience.

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2. The ketamine experience

During a KAP session, ketamine is administered according to the treatment plan established with your prescribing medical provider. The experience may involve changes in perception, awareness, and your relationship with thoughts and emotions. You will have a supportive therapeutic environment in which to explore the experience without pressure to talk or make sense of everything in the moment.

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3. Integration and lasting change

The work does not end when the medication wears off. Integration gives us an opportunity to reflect on your experience, explore emotions or insights that emerged, and connect them to your everyday life. Together, we can identify patterns, strengthen healthier perspectives, and translate what you learned into meaningful changes in how you relate to yourself and others.

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How Does Ketamine Affect the Brain?

Ketamine has gained attention for its effects on the brain, particularly its interaction with glutamate, a neurotransmitter involved in learning, memory, and communication between brain cells.

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Ketamine works differently from many traditional antidepressants. It interacts with NMDA receptors, influencing glutamate signaling and processes involved in neuroplasticity, or the brain's ability to form and reorganize connections.

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Research has explored several ways ketamine may influence the brain:

  • Glutamate signaling: Ketamine interacts with NMDA receptors and influences glutamate activity, which plays an important role in communication between neurons.

  • Neuroplasticity: Ketamine may support the brain's ability to form and strengthen new neural connections, creating opportunities for new patterns of thinking and responding.

  • BDNF: Ketamine influences brain-derived neurotrophic factor (BDNF), a protein involved in neuronal growth, survival, and connectivity.

  • Default Mode Network: Research suggests ketamine may influence activity within the brain's Default Mode Network, which is associated with self-referential thinking and rumination.

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These effects may help explain why some people experience changes in mood, perspective, or emotional flexibility following ketamine treatment. However, researchers are still working to understand exactly how ketamine produces its therapeutic effects.

The combination of medication and psychotherapy offers an opportunity to explore these changes within a supportive therapeutic relationship.

What can KAP help with?

KAP may be worth exploring for individuals experiencing:

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  • Depression and persistent low mood

  • Anxiety and chronic stress

  • Trauma and complex trauma

  • Emotional disconnection or feeling stuck

  • Negative thought patterns and rumination

  • Grief and unresolved emotional experiences

  • Difficulties with self-worth and identity

  • Patterns that feel difficult to change through traditional approaches alone​

KAP is not appropriate for everyone, and treatment suitability depends on individual history, medical considerations, and goals. We can discuss whether it may be a helpful addition to your current therapeutic work.

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Watch this video for more information on Ketamine Assisted Therapy (KAP)!

FAQs for KAP

What is ketamine?

Ketamine is a medication that has been used in medical settings for decades, primarily as an anesthetic and for pain management. More recently, it has received attention for its potential mental health benefits, particularly in the treatment of depression that has not responded to traditional approaches.

Ketamine works differently from many traditional antidepressants by interacting with the brain's glutamate system. This can influence neuroplasticity, or the brain's ability to form and reorganize connections. In KAP, ketamine is used alongside psychotherapy to create opportunities for emotional insight and therapeutic change.

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Is ketamine legal?

Yes. Ketamine is an FDA-approved medication used in medical settings. However, ketamine itself is not FDA-approved specifically for the treatment of depression, anxiety, or trauma. Medical providers may prescribe it off-label for certain mental health conditions when clinically appropriate. Treatment should always involve qualified medical oversight.

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How does ketamine feel?

Everyone's experience is different. Ketamine can temporarily alter your perception, awareness, sense of time, and connection to your surroundings. Some people describe feeling more introspective, emotionally open, or disconnected from their usual patterns of thinking. Others may experience visual imagery, changes in bodily sensations, or a sense of perspective that feels different from everyday awareness.

You may find that talking feels difficult during portions of the experience, and that is okay. There is no expectation to talk, explain, or make sense of everything while it is happening. The therapeutic work continues afterward through integration, where we can explore your experience together.

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How long does the ketamine experience last?

The duration depends on the route of administration, dosage, and individual response. The most noticeable effects of ketamine are generally temporary, although some people experience changes in mood or perspective that extend beyond the dosing session. The prescribing medical provider will discuss what to expect based on your specific treatment plan.

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How does ketamine work in the brain?

Ketamine interacts with NMDA receptors and influences glutamate signaling, which plays an important role in communication between brain cells. This process may support neuroplasticity, the brain's ability to form new connections and adapt.

Research also suggests ketamine may influence BDNF, a protein involved in brain cell growth and connectivity, as well as activity in networks associated with repetitive thinking and rumination.

These changes may help create opportunities to step outside familiar patterns and approach thoughts, emotions, and experiences differently. Researchers are continuing to study the mechanisms behind ketamine's therapeutic effects.

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Are there side effects or risks associated with ketamine?

Like any medication, ketamine has potential risks and side effects. Common short-term effects may include nausea, dizziness, increased blood pressure, changes in perception, dissociation, and drowsiness. Some people may experience anxiety or discomfort during the experience. There are also important medical considerations, including cardiovascular concerns, certain psychiatric conditions, medication interactions, and a history of substance misuse. Repeated or unsupervised ketamine use carries additional risks, including dependence and urinary complications. Your medical history and current medications should be reviewed by the prescribing provider before treatment. Medical oversight, appropriate screening, and following the prescribed treatment plan are essential parts of the process.

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Why combine ketamine with psychotherapy?

Ketamine can create a temporary shift in how you experience thoughts, emotions, and familiar patterns. Psychotherapy provides a space to explore those experiences, understand what they may mean, and work toward changes that extend beyond the session.

Rather than focusing solely on the medication experience, KAP incorporates preparation, therapeutic support, and integration. Together, we can identify patterns, explore emotional experiences, and translate insights into practical changes in your everyday life.

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How is KAP different from traditional talk therapy?

Traditional talk therapy often involves exploring experiences through conversation, reflection, and the gradual development of new perspectives. While this can be incredibly effective, some people find themselves understanding their patterns intellectually without feeling able to shift them emotionally.

KAP offers a different therapeutic experience. Ketamine may temporarily change your relationship with thoughts, emotions, and familiar ways of responding. This can create an opportunity to explore experiences from a different perspective. Therapy helps provide structure, support, and integration so that the experience can become part of a larger process of change.

KAP does not replace the importance of the therapeutic relationship or the work involved in making lasting changes.

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Do I need to have tried traditional therapy or medication first?

Not necessarily. However, your treatment history, current symptoms, goals, and medical history will all be considered when determining whether KAP is an appropriate option. Ketamine treatment is not a first-line solution for everyone, and a medical provider will help determine whether it is appropriate for you.

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Can KAP help with trauma?

KAP may be explored as part of treatment for individuals experiencing trauma and PTSD. Some people find that ketamine allows them to approach emotions or experiences from a different perspective. However, ketamine is not a standalone trauma treatment, and the experience does not guarantee that memories will be processed or resolved.

Preparation, emotional safety, pacing, and integration are especially important when working with trauma. We will consider your history, current stability, and therapeutic goals when determining whether KAP is appropriate.

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What if I am not sure whether KAP is right for me?

That is completely okay. You do not need to have everything figured out before reaching out. During an initial consultation, we can talk about what has brought you to therapy, what you are hoping to change, and whether KAP may be a helpful option.

We can also discuss how KAP might fit alongside other approaches, including EMDR, IFS, or ongoing individual therapy.

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Do you prescribe ketamine?

Ketamine is prescribed and medically managed by a qualified medical provider. My role is to provide the psychotherapy component of treatment, including preparation, therapeutic support, and integration. If you are interested in KAP, we can discuss the medical referral and evaluation process.

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Do you offer IV ketamine infusions?

Ketamine-assisted psychotherapy and IV ketamine infusions are not the same service. My role is to provide psychotherapy in coordination with an appropriately qualified medical provider. The route of administration and medication protocol will depend on the collaborating medical provider and your individualized treatment plan.

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Can I continue seeing my current therapist?

Yes. KAP does not necessarily require you to discontinue working with your established therapist. In some cases, KAP can complement ongoing therapy by providing additional opportunities for exploration and processing. With your written authorization, I can coordinate with your existing therapist to support continuity of care and integration.

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Ketamine-Assisted EMDR: Combining Two Therapeutic Approaches

Ketamine and EMDR can also be incorporated together as part of an individualized therapeutic approach. Ketamine may temporarily influence emotional processing and cognitive flexibility, while EMDR uses bilateral stimulation to help the brain process distressing memories and experiences.

For some individuals, combining these approaches may offer another way to engage in trauma-focused work. This approach requires careful preparation, appropriate medical oversight, and clinical consideration to determine whether it is a good fit.

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Learn More About Ketamine-Assisted EMDR 

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How do I get started?

The first step is scheduling an initial consultation. We will discuss your goals, therapeutic history, and what you are hoping to get out of KAP. If it seems like a potential fit, we can discuss next steps, including medical evaluation and coordination with the prescribing provider.

You are welcome to reach out with questions before deciding whether to move forward.

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I offer a free initial consultation to help you explore whether Ketamine-Assisted Psychotherapy may be a good fit for you.

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Ketamine Assisted Psychotherapy in Scottsdale Arizona

Natalie Foster Therapy

Therapy for adults ready to heal, grow, and create lasting change in Scottsdale, Arizona.

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